“It’s a plumbing problem.”
— Jonathan Kipnis, PhD
Director, Brain Immunology and Glia (BIG) Center
Washington University
What is CerebroLab?
CerebroLab is an AI driven technology that leverages peer-reviewed research and clinical evidence to offer personalized education and information for complex Neurodegenerative disease (NDD) diagnoses.
Why CerebroLab?
CerebroLab draws from a body of contemporary research that is overlooked by standard of care diagnostic and clinical models. Primary among these is 2024 research highlighting the impact of the Glycocalyx on the Blood Brain Barrier and the 2012 discovery of the Glymphatic system.
These findings suggest that neurodegenerative disease may be the cascading outcome of disruption to cerebral blood flow and the glymphatic system causing vasculopathy and protein aggregation.
GLYCOCALYX
The glycocalyx (GCX) is a thin, carbohydrate-rich layer that covers the surface of the blood vessels and regulates the flow of blood, fluid and cells in and out of blood vessels. Dysregulation or loss of the GCX has been implicated in the progression of neurodegenerative diseases, highlighting its potential as a target for future diagnostics and therapies.
GLYMPHATIC SYSTEM
The glymphatic system is a waste clearance pathway in the brain that removes metabolic byproducts, including amyloid and tau proteins. It is a network of perivascular pathways in the brain that allows cerebrospinal fluid (CSF) to flow through the brain tissue and interact with the interstitial fluid (ISF).